Cell behaviour towards different wettable biomaterials surfaces: Functional role of integrins in intracellular signalling processes

FAUCHEUX

Project timeline
Start:
September 2001
Duration:
24 months
End:
August 2003
General Information
This interdisciplinary project covers a wide range from material sciences to cell biology and aims at a better understanding of the tissue compatibility of biomaterials. Existing knowledge on the activity of integrins on biomaterials available at Helmholtz-Zentrum Geesthacht will be combined with the knowledge and expertise in intracellular signalling processes, particularly on cAMP, which will be brought into the project by the M.-C. fellow, Dr Nathalie Faucheux. A particular focus is on how adsorption of adhesive proteins like vitronectin, fibronectin, and others on well defined surfaces such as self assembling monolayers interact with integrins and influence intracellular signalling pathways. Results will be used in biohybrid organ technology and tissue engineering.
EU-Programme Acronym and Subprogramme AreaFP5-HUMAN POTENTIAL-2000, Marie-Curie Individual Fellowship
Project TypeMarie-Curie Individual Fellowship
Contract NumberHPMF-CT-2000-00883
Co-ordinatorHelmholtz-Zentrum Geesthacht (D)
Total Eligible Costs (€) HZG Eligible Costs (€) EC Funding for HZG (€)
147.150147.150
Contact Person at HZG Univ.-Prof. Dr. sc. nat. Andreas Lendlein, Institute of Biomaterial Science, Phone: +49 3328-352-450, (initial contact: Dr. Thomas Groth, Institute of Polymer Research)
E-mail contact
Worldwide Europe

Participants
Université de Technologie de Compiègne (FR)

(completed August 2003)

Last Update: 01. June 2017