Biological Characterisation

Selected Publications

Review articles

  • Luthringer B.J.C., F. Feyerabend, R. Willumeit-Römer (2014): Magnesium-based implants: a mini review. Magnesium Research 27(4):142-154.
  • Luthringer B.J.C., N. Hort, F. Feyerabend (2012): Metal Matrix Composites: Magnesium. In: Encyclopedia of Composites, 2nd Edition, Editors: Luigi Nicolais, Assunta Borzacchiello, John Wiley &Sons, Hoboken, New Jersey 1756-1777
  • Martinez Sanchez Adela Helvia, Bérengère Luthringer, Frank Feyerabend, Regine Willumeit (2015): Mg and Mg alloys: How comparable are in vitro and in vivo corrosion rates? - A Review. Acta biomaterialia 13:16-31. http://dx.doi.org/10.1016/j.actbio.2014.11.048

Further articles

  • Burmester Anna, Regine Willumeit-Römer, Frank Feyerabend (2017): Behavior of bone cells in contact to magnesium implant material. Journal of Biomedical Materials Research B,105(1):165-179. DOI: 10.1002/jbm.b.33542
  • Golub M., S. Combet, D.C.F. Wieland, D. Soloviov, A. Kuklin, H. Lokstein, F.-J. Schmitt, R. Olliges, M. Hecht, H.-J. Eckert , J. Pieper (2017): Solution structure and excitation energy transfer in phycobiliproteins of Acaryochloris marina investigated by small angle scattering, BBA – Bioenergetics
  • Marco Iñigo, Anastasia Myrissa, Elisabeth Martinelli, Frank Feyerabend, Regine Willumeit-Römer, Annelie Martina Weinberg, Omer van der Biest (2017): In vivo and in vitro biodegradation comparison of pure Mg, Mg10Gd and Mg2Ag: a short term study. European Cells and Materials 33:90-104. DOI:10.22M20g3 d/eeCgrMad.va0ti3o3na 0co7
  • Martinez-Sanchez, A. H., Feyerabend, F., Laipple, D., Willumeit-Römer, R., Weinberg, A., Luthringer, B. J. (2017): Chondrogenic differentiation of ATDC5-cells under the influence of Mg and Mg alloy degradation. Materials Science and Engineering: C, 72, 378-388. http://dx.doi.org/10.1016/j.msec.2016.11.062
  • Mohedano, M., B.J.C. Luthringer, B. Mingo, F. Feyerabend, R. Arrabal, P. J. Sanchez-Egido, C. Blawert, R. Willumeit-Römer, M.L. Zheludkevich, E. Matykina: Bioactive plasma electrolytic oxidation coatings on Mg-Ca alloy to control degradation behavior. Surface and Coatings Technology 315, 454-467. http://dx.doi.org/10.1016/j.surfcoat.2017.02.050
  • Myrissa, A., Braeuer, S., Martinelli, E., Willumeit-Römer, R., Goessler, W., Weinberg, A.M. (2017): Gadolinium accumulation in organs of Sprague-Dawley® rats after implantation of a biodegradable magnesium-gadolinium alloy. Acta Biomaterialia 48, 521-529. doi: 10.1016/j.actbio.2016.11.024.
  • Raj A., M. Wang, Th. Zander, D.C. F. Wieland, X. Liu, J. An, V. M. Garamus, R. Willumeit-Römer, M. Fielden, P. M. Claesson, A. Dėdinaitė (2017): Lubrication Synergy: Mixture of Hyaluronan and Dipalmitoylphosphatidylcholine (DPPC) Vesicles. Journal of Colloid and Interface Science, 488:225–233. JCIS-16-2765R1
  • Zaatreh Sarah, Haffner David, Strauß Madlen, Wegner Katharina, Warkentin Mareike, Lurtz Claudia, Zamponi Christiane, Mittelmeier Wolfram, Kreikemeyer Bernd, Willumeit-Römer Regine, Quandt Eckhard, Bader Rainer (2017): Fast corroding, thin magnesium coating displays antibacterial effects and low cytotoxicity. Biofouling Vol. 0 , Iss. 0,0. DOI: 10.1080/08927014.2017.1303832
  • Ahmad Agha Nezha, Regine Willumeit-Römer, Daniel Laipple, Bérengère Luthringer, Frank Feyerabend (2016): The Degradation Interface of Magnesium Based Alloys in Direct Contact with Human Primary Osteoblasts Cells. PloS one 11(6):e0157874. DOI: 10.1371/journal.pone.0157874
  • Ahmad Agha, Nezha, Frank Feyerabend, Boriana Mihailova, Stefanie Heidrich, Ulrich Bismayer and Regine Willumeit-Römer (2016): Magnesium Degradation Influenced by Buffering Salts in Concentrations Typical of In vitro and In vivo Models. Materials science and engineering. Available online: 18 September 2015. print: Materials Science and Engineering C 58:817–825. DOI: 10.1016/j.msec.2015.09.067
  • Deing Axel, Thomas Ebel, Regine Willumeit-Römer, and Bérengère Luthringer (2016): Comparison of the Influence of Phospholipid-Coated Porous Ti-6Al-4V Material on the Osteosarcoma Cell Line Saos-2 and Primary Human Bone Derived Cells. Metals 6(3):66. DOI:10.3390/met6030066
  • Feyerabend, Frank, Dose, Thomas, Xu, Yuling, Beckmann, Felix, Stekker, Michael, Willumeit-Römer, Regine, Schreyer, Andreas, Wilde, Fabian, Hammel, Jörg U. (2016): Magnesium degradation observed in situ under flow by synchrotron radiation based microtomography. Proc. SPIE 9967, Developments in X-Ray Tomography X, 99671X. doi:10.1117/12.2241085
  • Galli Silvia, Jörg U. Hammel, Julia Herzen, Timo Damm, Ryo Jimbo, Felix Beckmann, Ann Wennerberg, Regine Willumeit-Römer (2016): Evaluation of the degradation behavior of resorbable metal implants for in vivo osteosynthesis by synchrotron radiation based x-ray tomography and histology. Proc. SPIE 9967, Developments in X-Ray Tomography X, 996704. doi:10.1117/12.2237563
  • Jähn Katharina, Hiroaki Saito, Hanna Taipaleenmäki, Andreas Gasser, Norbert Hort, Frank Feyerabend, Hartmut Schlüter, Johannes M. Rueger, Wolfgang Lehmann, Regine Willumeit-Römer, Eric Hesse (2016): Intramedullary Mg-2Ag nails augment callus formation during fracture healing in mice. Acta Biomaterialia 36:350-360
  • Lu, Y., Huang, Y., Feyerabend, F., Willumeit-Römer, R., Kainer, K.U., Hort, N. (2016): In vitro corrosion and cytocompatibility properties of Mg-2Gd-X(Ag, Ca) alloys. Magnesium Technology 2016:347-351.
  • Luthringer, B.J.C.; Willumeit-Roemer, R. (2016): Effect of magnesium degradation products on mesenchymal stem cell fate and osteoblastogenesis. Gene 575(1):9-20. DOI: 10.1016/j.gene.2015.08.028
  • Mostofi, S; Bonyadi Rad, E; Wiltsche, H; Fasching, U; Szakacs, G; Ramskogler, C; Srinivasaiah, S; Ueçal, M; Willumeit, R; Weinberg, AM; Schaefer, U. (2016): Effects of Corroded and Non-Corroded Biodegradable Mg and Mg Alloys on Viability, Morphology and Differentiation of MC3T3-E1 Cells Elicited by Direct Cell/Material Interaction. PLoS ONE 11(7):e0159879. doi:10.1371/journal.pone.0159879
  • Myrissa Anastasia, Nezha Ahmad Agha, Yiyi Lu, Elisabeth Martinelli, Johannes Eichler, Gabor Szakacs, Claudia Kleinhans, Regine Willumeit- Römer, Ute Schäfer. Annelie-Martina Weinberg (2016): In vitro and in vivo comparison of binary Mg alloys and pure Mg. Materials Science and Engineering C 61:865-874. doi:10.1016/j.msec.2015.12.064
  • Nene, Saurabh Sanjay, Estrin, Yuri, Kashyap, Bhagawati Prasad, Prabhu, Nithyananad, Al-Samman, Talal, Luthringer, Berengere JC, Willumeit, Regine (2016): Towards microstructure-cytocompatibility relationship in ultralight Mg-4Li-1Ca (LX41) alloy for degradable implant applications. BioNanoMaterials 17(3):103-111
  • Nyrow Alexander, Christian Sternemann John S. Tse,Christoph J. Sahle Kolja Mende, Florian Wieland, Robert A. Gordon Tom Regier,Max Wilke and Metin Tolan (2016): Bulk sensitive determination of the Fe3+/FeTot-ratio in minerals by Fe L2/3 -edge X-ray Raman scattering spectroscopy. Journal of Analytical Atomic Spectrometry 31(3):815-820. DOI:10.1039/C5JA00261C
  • Scharfenberg Dorothee, Bérengère Luthringer, Katrin Lamszus, Regine Willumeit-Römer (2016): Glioblastoma Cell Type-Specific Loading with Iron Oxide Magnetic Nanoparticles. BioNanoScience 6(4):297-307. DOI: 10.1007/s12668-016-0363-1.
  • Tie D, Guan R, Liu H, Cipriano A, Liu Y, Wang Q, Huang Y, Hort N (2016): An in vivo study on the metabolism and osteogenic activity of bioabsorbable Mg-1Sr alloy. Acta Biomater. 29:455-67. doi: 10.1016/j.actbio.2015.11.014 PMID: 26577986
  • Wieland D.C.F., V. Garamus, T. Zander, C. Krywka, M. Wang, A. Dedinaite, P. Claesson and R. Willumeit-Römer (2016): Studying solutions at high shear rates -- a dedicated microfluidics setup. J. Synchrotron Rad. 23:480-486. DOI: 10.1107/S1600577515024856
  • Wieland Florian D.C., Patrick Degen, Thomas Zander, Sören Gayer, Akanksha Raj, Junxue An, Andra Dëdinaitë, Per Claesson, Regine Willumeit-Römer (2016): Structure of DPPC–hyaluronan interfacial layers – effects of molecular weight and ion composition. Soft Matter 12:729-740. DOI: 10.1039/C5SM01708D
  • Zander T., D.C.F. Wieland, A Raj, M. Wang, B. Nowak, C. Krywka, A. Dėdinaitė, P. M. Claesson, V. M. Garamus, A. Schreyer, R. Willumeit-Römer (2016): The Influence of Hyaluronan on the Structure of a DPPC – Bilayer under High Pressures. Colloids and Surfaces B: Biointerfaces 142:230-238. doi.org/10.1016/j.colsurfb.2016.02.040
  • Zhen Zhen, Bérengère Luthringer, Li Yang, Tingfei Xi, Yufeng Zheng, Frank Feyerabend, Regine Willumeit-Roemer, Chen Lai, Zigang Ge (2016): Proteomic profile of mouse fibroblasts exposed to pure magnesium extract. Materials science & engineering C, Materials for biological applications 2016, 69:522-531. DOI: 10.1016/j.msec.2016.06.100
  • Burmester Anna, Regine Willumeit-Römer, Frank Feyerabend (2015): Behavior of bone cells in contact to magnesium implant material. J Biomed Mater Res Part B 2015:165–179.
  • Cecchinato Francesca, Nezha Ahmad, Adela Martinez, Berengere Luthringer, Frank Feyerabend, Ryo Jimbo, Regine Willumeit, Ann Wennerberg (2015): Influence of Magnesium Alloy Degradation on Undifferentiated Human Cells. PLoS ONE 10(11):e0142117. doi:10.1371/journal.pone.0142117
  • Charyeva Olga, Frank Feyerabend, Regine Willumeit, Daniel Zukowski, Cyrille Gasqueres, Gabor Szakacs, Nezha Ahmad Agha, Norbert Hort, Felix Gensch, Francesca Cecchinato, Ryo Jimbo, Ann Wennerberg, Katrin Susanne Lips (2015): In Vitro Resorption of Magnesium Materials and its Effect on Surface and Surrounding Environment. MOJ Toxicology 1(1):00004. DOI: 10.15406/mojt.2015.01.00004
  • Degen Patrick, D.C. Florian Wieland, Christian Strötges, Metin Tolan, Heinz Rehage (2015): Mixed Layers of Non-ionic Dendritic Amphiphiles and DPPC at the Water Surface. Langmuir 31(43):11851-11857. DOI: 10.1021/acs.langmuir.5b02702
  • Martinez Sanchez Adela Helvia, Bérengère Luthringer, Frank Feyerabend, Regine Willumeit (2015): Mg and Mg alloys: How comparable are in vitro and in vivo corrosion rates? - A Review. Acta biomaterialia 13:16-31. http://dx.doi.org/10.1016/j.actbio.2014.11.048
  • Nene, S. S., Y. Estrin, B.P. Kashyap, N. Prabhu, T. Al-Samman, B.J.C. Luthringer, R. Willumeit (2015): Introducing an ultralight, high-strength, biodegradable Mg-4Li-1Ca alloy. Advanced Biomaterials and Devices in Medicine 2(1):32-36.
  • Wang M., T. Zander, X. Liu, C. Liu, A. Raj, D.C.F. Wieland, V. M. Garamus, R. Willumeit-Römer, P. M. Claesson, A. Dëdinaitë (2015): The effect of temperature on supported dipalmitoylphosphatidylcholine (DPPC) bilayers: Structure and lubrication performance. Journal of Colloid and Interface Science 445:84–92. http://dx.doi.org/10.1016/j.jcis.2014.12.042
  • Wieland, DCF, C Krywka, E Mick, R Willumeit-Römer, R Bader and D Kluess (2015): Investigation of the Inverse Piezoelectric Effect of Trabecular Bone on a Micrometer Lengthscale Using Synchrotron Radiation. Acta biomaterialia 25:339–346. doi.org/10.1016/j.actbio.2015.07.021
  • Wu, Lili, Frank Feyerabend, Arndt F Schilling, Regine Willumeit-Römer and Bérengère JC Luthringer (2015): Effects of Extracellular Magnesium Extract on the Proliferation and Differentiation of Human Osteoblasts and Osteoclasts in Coculture. Acta Biomaterialia 27:294–304. pii: S1742-7061(15)30086-6. doi: 10.1016/j.actbio.2015.08.042.
  • Burmester A, Feyerabend F, Willumeit R (2014): Behavior of bone cells due to contact to magnesium implant material. European Cells and Materials 28:28.
  • Burmester A, Luthringer B, Willumeit R, Feyerabend F (2014): Comparison of the reaction of bone-derived cells to enhanced MgCl2-salt concentrations Biomatter 4(1):e967616. DOI 10.4161/21592527.2014.967616
  • Cecchinato F C, Agha N, Martinez A, Luthringer B, Jimbo R, Wennerberg A, Feyerabend F, Willumeit R. (2014): Influence of binary magnesium alloys corrosion on morphology and adhesion of human undifferentiated cells. European Cells and Materials 28:49.
  • Deing A., B. Luthringer, D. Laipple, T. Ebel, R. Willumeit (2014): A porous TiAl6V4 implant material for medical application. International Journal of Biomaterials Volume 2014, Article ID 904230, 8 pages, http://dx.doi.org/10.1155/2014/904230
  • Kerschnitzki M., T. Zander, P. Zaslansky, P. Fratzl, R. Shahar, W. Wagermaier (2014): Rapid Alterations of Avian Medullary Bone Material during the Daily Egg-laying Cycle. Bone 69:109–117. doi:10.1016/j.bone.2014.08.019
  • Luthringer B. J.C., U.M. Katha, R. Willumeit (2014): Phosphatidyl-ethanolamine biomimetic coating increases mesenchymal stem cell osteoblastogenesis. J Mater Sci Mater Med. 25(11):2561-2571.
  • Luthringer BJ, Feyerabend F, Willumeit-Römer R. (2014): Magnesium-based implants: a mini-review. Magnesium Research 27:142-154
  • Martínez-Sánchez A, Feyerabend F, Luthringer B, Willumeit R. (2014): Effect of magnesium extracts on the chondrogenic differentiation of HUCPV cells. European Cells and Materials 28:69.
  • Sahle Ch.J., C. Sternemann, H. Sternemann, J.S. Tse, R.A. Gordon, S. Desgreniers, S. Maekawa, S. Yamanaka, F. Lehmkühler, D.C.F. Wieland, K. Mende, S. Huotari, and M. Tolan (2014): The Ba 4d–4f giant dipole resonance in complex Ba/Si compounds. Journal of Physics B: Atomic, Molecular and Optical Physics 47(4):045102
  • Wieland D.C. Florian, Patrick Degen, Michael Paulus, Martin A. Schroer, Heinz Rehage, Metin Tolan (2014): pH controlled condensation of polysiloxane networks at the water-air interface. Colloids and Surfaces A 455:44-48.
  • Willumeit R., A. Möhring and F. Feyerabend (2014): Optimization of cell adhesion on Mg based implant materials by pre-incubation under cell culture conditions. Int. J. Mol. Sci. 15(5):7639-7650. doi:10.3390/ijms15057639
  • Wu, Lili, Bérengère J.C. Luthringer, Frank Feyerabend, Arndt F. Schilling, Regine Willumeit (2014): Effects of extracellular magnesium on differentiation and function of human osteoclasts. Acta Biomaterialia 10(6):2843-2854. http://dx.doi.org/10.1016/j.actbio.2014.02.010
  • Bursy M., M. Paulus, P. Degen, S. Wulle, D.C.F. Wieland, H. Rehage, M. Tolan (2013): Silver nanoparticles at charged membrane. Journal of Chemical and Biological Interfaces 1(2):138-140.
  • Golub M., D. Lott, E. Watkins, V. M. Garamus, B. Luthringer, M. Stoermer, A. Schreyer, and R. Willumeit (2013): X-ray and Neutron Investigation of a Self-Assembled Monolayer of N-Octadecylphosphonic Acid on a Titanium Surface. Biointerphases 8:21. http://dx.doi.org/10.1186/1559-4106-8-21
  • Grünherz L., L. Wu, N. Wojtas, F. Kleinmichel, C. I. Günter, H.-G. Machens, A. F. Schilling (2013): Osteoklastäre Resorption osteologischer Biomaterialien. Osteologie 22(3):200-205.
  • Luthringer B.J.C., F. Ali, H. Akaichi, F. Feyerabend, T. Ebel, and R. Willumeit (2013): Production, characterisation, and cytocompatibility of porous Ti-6Al-4V particulate scaffolds. J Mater Sci: Mater Med 24:2337-2358. DOI 10.1007/s10856-013-4989-z
  • Wieland D.C.F., P. Degen, M. Paulus, M.A. Schroer, S. Bieder, Ch.J. Sahle, J. Möller, S. Leick, Z. Chen, B. Struth, H. Rehage, and M. Tolan (2013): Formation if iron containing aggregates at the liquid-air interface. Colloids and Surfaces B: Bioninterfaces 109:74-81.
  • Willumeit R., F. Feyerabend, N. Huber (2013): Magnesium degradation as determined by artificial neural networks. Acta Biomat 9(10):8722-8729.
  • Luthringer B.J.C., N. Hort, and F. Feyerabend (2012): Metal Matrix Composites: Magnesium. Wiley Encyclopedia of Composites 1–23. DOI: 10.1002/9781118097298.weoc144
  • Petrenko V. I., M. V. Avdeev, L. A. Bulavin, L. Vekas, L. Rosta, V. M. Garamus, R. Willumeit, V. L. Aksenov (2012): Diagnostic and analysis of aggregation stability of magnetic fluids for biomedical applications by small-angle neutron scattering. Journal of Physics: Conference Series 345:012028. doi:10.1088/1742-6596/345/1/012028

Theses

  • Adela Helvia Martinez (2017): Cell reactions to the degradation of Mg-based materials: chondrogenic differentiation. Hamburg University, Department of Chemistry, Faculty of Mathematics, Informatics and Natural Sciences
  • Dorothee Rose, geb. Scharfenberg (2017): Magnetization and movement of glioblastoma cells loaded with magnetic nanoparticles. Hamburg University, Faculty of Chemistry
  • Thomas Zander (2016): The interaction of DPPC and hyaluronan. Fakultät für Mathematik,
    Informatik und Naturwissenschaften, Fachbereich Physik der Universität Hamburg
  • Anna Müller (geb. Burmester, 2016): Genetic regulation of osteoblastic cells in reaction to a magnesium corrosion environment. Universität Hamburg, Fachbereich Chemie, Institut für Biochemie und Molekularbiologie
  • Nezha Ahmad Agha (2016): Biodegradation study on magnesium-based materials under physiological conditions. Technical faculty, Christian-Albrechts-University Kiel
  • Maria Costatino (2016): Early cells interaction on magnesium based materials. Faculty of Mathematics, Informatics and Natural Sciences Department of Chemistry, Hamburg University
  • Björn Wiese (2016): The Effect of CaO on Magnesium and Magnesium Calcium Alloys. TU Clausthal
  • Lili Wu (2015): In Vitro Assessment of the Cytocompatibility of Magnesium-Based Implant Materials with Osteoclasts Hamburg University
  • Eshwara Nidadavolu (2016): Degradation behavior of Mg-Ca alloys. Christian-Albrechts-Universität zu Kiel, Technische Fakultät
  • Niranjan Ramakrishnegowda (2016): Development of Layered Mg-Ti Composites for Biomedical Applications. Technische Fakultät, CAU Kiel
  • Markus Steiner (2016): Influence of acetic acid etching on the degradation behaviour of Mg-5Gd alloy. Christian-Albrechts-University Kiel
  • Sascha Bußacker (2017): Untersuchung mechanischer Eigenschaften eines Titan-Magnesium-Schichtaufbaus. HAW Hamburg, Department Maschinenbau und Produktion
  • Niklas Rüder (2016): Degradation von mittels Metallpulver-Spritzguss prozessierten Mg-Ca Legierungen. TUHH
  • Sebastian Meyer: Einfluss des Gefüges auf die mechanischen und Degradationseigenschaften, neuer stranggepresster Magnesiumlegierungen. Technische Fakultät der Christian-Albrecht-Universität zu Kiel
  • Jonas Olsson: Parameterstudie: Das Drahterodieren von Magnesium. Fachhochschule Lübeck, Fachbereich Maschinenbau und Wirtschaft