Marine Bioanalytical Chemistry

Publications

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since 2012
2007 - 2012
  • Kakuschke A, Pröfrock D, Prange A (2012) C-reactive protein in blood plasma and serum samples of harbour seals ( Phoca vitulina ). Marine Mammal Science doi: 10.1111/j.1748-7692.2012.00603.x
  • Helmholz H, Wiebring A, Lassen S, Ruhnau Ch, Schütt Ch, Prange A (2012) Cnidom analysis combined with an in vitro evaluation of the lytic, cyto- and neurotoxic potential of Cyanea capillata (Cnidaria:Scyphozoa). Scientia Marina 76, 339-348 DOI: 10.3989/scimar.03381.16E
  • Kakuschke A, Gandrass J, Luzardo O P, Boada L D, Zaccaroni A, Griesel S, Grebe M, Pröfrock D, Erbslöh B, Valentine - Thon E, Prange A, Kramer K (2012) Postmortem Health and Pollution Investigations on Harbor Seals (Phoca vitulina) of the Islands Helgoland and Sylt. International Scholary Research Network Zoology doi: 10.5402/2012/106259
  • Grebe M, Pröfrock D, Kakuschke A, del Castillo Busto ME, Montes-Bayon M, Sanz-Medel A, Broekaert J, Prange A (2012) Comparison of different methods for the absolute quantification of harbor seal transferrin glycoforms using HPLC-ICP-MS. JAAS 37, 440-448
  • Lassen S, Wiebring A, Helmholz H, Ruhnau Ch, Prange A (2012) Isolation of a Nav channel blocking polypeptide from Cyanea capillata medusae - A neurotoxin contained in fishing tentacle isorhizas. Toxicon 59, 610-616
  • Grebe M, Pröfrock D, Kakuschke A, Broekaert J, Prange A (2011) Absolute quantitation of transferrin in blood samples of harbour seals using HPLC-ICP-MS. Metallomics 3(2), 176 - 185
  • Kakuschke A, Valenthine-Thon E, Griesel S, Fonfara S, Siebert U, Prange A (2011) Are metal-induced hypersensitivities in harbor seals associated with liver function? Marine Pollution Bulletin, doi: 10.1016/j.marpolbul.2011.05.034
  • Helmholz H (2011) Natural Substances of Marine Origin with Toxic Properties. in Quante M (et al. (eds): Persistent Pollution - Past, Present and Future. Chapter 17, 319-335
  • Lassen S, Helmholz H, Ruhnau C, Prange A (2011) A novel proteinaceous cytotoxin from the northern Scyphozoa Cyanea capillata (L.) with structural homology to cubozoan hemolysins. Toxicon 57, 721 - 729
  • Helmholz H, Dong Z, Ruhnau Ch, Liu D (2011) Investigation on fish gill cell toxicity and haemolytic activity of Nemopilema nomurai (Scyphozoa, Rhizostoma) from the northern Yellow Sea of China. Current Topics in Toxicology 7, 79-87
  • Kakuschke A, Valentine-Thone E, Griesel S, Gandrass J, Perez Luzardo O, Dominguez Boada L, Zumbado Pena M, Almeida Gonsalez M, Grebe M, Proefrock D, Erbslöh H-B, Kramer K, Fonfara S, Prange A (2010) First health and pollution study on harbor seals (Phoca vitulina) living in the German Elbe estuary. Mar Pol Bul 60, 2079-2086
  • Pröfrock D (2010) Progress and possibilities of using miniaturized separation techniques and element mass spectrometry for quantitative bio-analysis. Analytical and Bioanalytical Chemistry 389, 2383-2401
  • Kakuschke A, Erbslöh H-B, Griesel S, Prange A (2010) Acute phase haptoglobin in blood plasma samples of harbor seals (Phoca vitulina) of the Wadden Sea and of the island of Helgoland. Comparative Biochemistry and Physiology, Part B 155, 67-71
  • Prange A, Pröfrock D (2010) Sample introduction in ICP-MS: Capillary electrophoresis. In Beauchemin D and Mattews DE (eds) The Encyclopedia of Mass Spectrometry 5, 46-58
  • Helmholz H (2010) Selelective toxin-lipid membrane interactions of natural, haemolytic Scyphozoan toxin analyzed by surface plasmon resonance. Biochimica et Biophysica Acta - Biomembranes 1798, 1944-1952
  • Wiebring A, Helmholz H, Lassen S, Prange A, Jarms G (2010) Separation and analysis of different types of nematocysts from Cyanea capillata (L.) medusae, Hydrobiologia 645, 203-212
  • Lassen S, Helmholz H, Ruhnau Ch, Prange A (2010) Characterisation of neurotoxic polypeptides from Cyanea capillata medusae (Scyphozoa). Hydrobiologia 645, 213-221
  • Pröfrock D (2010) Hyphenation of capillary-LC with ICP-MS and parallel on-line micro fraction collection for MALDI-TOF-TOF analysis - complementary tools for protein phosphorylation analysis. JAAS 25, 334-344
  • Wiebring A, Helmholz H, Sötje I, Lassen S, Prange A, Tiemann H (2010) Development of a new micromanipulation method for the separation of different types of nematocysts utilizing laser catapulting. Journal of Marine Biotechnology 12, 308-317
  • Helmholz H, Johnston B, Ruhnau Ch, Prange A (2010) Gill cell toxicity of northern boreal scyphomedusae Cyanea capillata and Aurelia aurita measured by an in vitro cell assay. Hydrobiologia 645, 223-234
  • Grebe M, Pröfrock D, Kakuschke A, Broekaert J, Prange A (2010) Metallomics approach for the identification of the iron transport protein transferrin in blood from harbour seals (Phoca vitulina). Metallomics 2(10), 683-693
  • Fahrenholtz S, Griesel S, Pröfrock D, Kakuschke A (2009) Essential and non-essential elements in tissues of harbour porpoises (Phocoena phocoena) stranded on the coasts of the Northern and Baltic Seas between 2004-2006. Journal of Environmental Monitoring 11, 1107-1113
  • Kakuschke A, Griesel S, Fonfara S, Rosenberger T, Prange A (2009) Concentrations of essential and non-essential elements in blood of harbor seals (Phoca vitulina) pups of the German North Sea. Biological Trace Element Research 127, 28-36
  • Künstl L, Griesel S, Prange A, Gössler W (2009) Arsenic speciation in body fluids of harbor seals (Phoca vitulina) and harbor porpoises (Phocoena phocoena). Environmental Chemistry 6, 319-327
  • Rosenfeld H, Lassen S, Prange A (2009) Characterization of haptoglobin in blood plasma of harbour seals (Phoca vitulina). Journal of Proteome Research 8, 2923-2932
  • Kakuschke A, Valentine-Thon E, Fonfara S, Kramer K, Prange A (2009) Effects of methyl-, phenyl-, ethylmercury and mercurychloride on immune cells of harbor seals (Phoca vitulina). Journal of Environmental Sciences 21, 1716-1721
  • Pröfrock D, Prange A (2009) Compensation of gradient related effects when using capillary liquid chromatography and inductively coupled plasma mass spectrometry for the absolute quantification of phosphylated peptides. Journal of Chromatography A 1216, 6706-6715
  • Griesel S, Kakuschke A, Siebert U, Prange A (2008) Trace Element Concentrations in Blood of Harbor Seals (Phoca vitulina) from the Wadden Sea. Science of the Total Environment 392, 313-323
  • Kakuschke A, Valentine-Thon E, Griesel S, Rosenberger T, Mundry R, Siebert U, Prange A (2008) Blood metal levels and metal-influenced immune functions of harbour seals in captivity. Mar Poll Bul 56, 764-769
  • Hasselmeier I, Fonfara S, Driver J, Siebert U (2008) Differential hematotoly profiles of free-ranging, rehabilitated and captive harbour seals (Phoca vitulina) of the german North Sea. Aquatic Mammals 34, 149-156
  • Kakuschke A, Valentine-Thon E, Fonfara S, Griesel S, Rosenberger T, Siebert U, Prange A (2008) Metal-induced impairment of the cellular immunity of newborn harbour seals (Phoca vitulina). Archives of Environmental Contamination and Toxicology 55, 129-136
  • Helmholz H, Naatz S, Lassen S, Prange A (2008) Isolation of a cytotoxic glycoprotein from the Scyphozoa Cyanea lamarckii by lectin-affinity chromatography and characterization of molecule interactions by surface plasmon resonance. Journal of Chromatography B 871, 60-66
  • Fonfara S, Kakuschke A, Rosenberger T, Siebert U, Prange A (2008) Changes of cytokine and acute phase protein expression in blood samples of harbour seal pups during their first months of marine life. Marine Biology 155, 337-345
  • Prange A, Pröfrock D (2008) Chemical labels and natural element tags for the quantitative analysis of bio-molecules. J Anal At Spectrom 23, 432-459
  • Wright AJ, Aguilar Soto N, Baldwin AL, Bateson M, Beale CM, Clark C, Deak T, Edwards EF, Fernandez Rodriguez A, Godinho A, Hatch l, Kakuschke A, Lusseau D, Martineau D, Romero LM, Weilgart L, Wintle B, Notarbartolo di Sciara G, Martin V (2007) Anthropogenic noise as a stressor in animals: a multidisciplinary perspective. International Journal of Comparative Psychology 20, 250-273
  • Kakuskche A, Prange A (2007) The influence of metal pollution on the immune system - a potential stressor for marine mammals in the North Sea. International Journal of Comparative Psychology 20, 179-193
  • Wright AJ, Aguilar Soto N, Baldwin AL, Bateson M, Beale CM, Clark C, Deak T, Edwards EF, Fernandez Rodriguez A, Godinho A, Hatch L, Kakuschke A, Lusseau D, Martineau D, Romero LM, Weilgart L, Wintle B, Notarbartolo di Sciara G, Martin V (2007) Do marine mammals experience stres related to anthropogenic noise? International Journal of Comparative Psychology 20, 274-31
  • Fonfara S, Siebert U, Prange A (2007) Cytokines as markers for infection in harbour porpoises (Phoconea phocoena). Marine Mammal Science 23, 931-942
  • Sonne C, Fonfara S, Dietz R, Kirgegaard M, Letcher R, Shahmiri S, Anderson S, Moller P (2007) Multiple cytokine and acute-phase protein gene transcription in West Greenland sledge dogs (Canis familaris) dietary exposed to organic environmental pollutants. Archives of Environmental Contamination and Toxicology 53, 110-118
  • Helmholz H, Ruhnau Ch, Schütt Ch, Prange, A (2007) Comparative study on the cell toxicity and enzymatic activity of two northern scyphozoan species Cyanea capillata (L.) and Cyanea lamarckii (Péron & Léslueur). Toxicon 50, 53-64
  • Lehnert K, Fonfara S, Wohlsein P, Siebert U (2007) Whale lice ( Isocyamus delphinii ) on a harbour purpoise ( Phocoena phocoena ) from German waters. Veterinary Record 161, 526-528
  • Fonfara S, Siebert U, Prange A, Colijn F (2007) The impact of stress on cytokine and haptoglobin mRNA expression in blood samples from harbour porpoises Phocoena phocoena. Journal of the marine Biological Association of the United Kingdom, 87, 305-311
2004 - 2006
  • Bettmer J, Jakubowski N, Prange A (2006) Elemental Tagging in Inorganic Mass Spectrometric Bioanalysis. Analytical and Bioanalytical Chemistry, 386, 7-11
  • Montes-Bayon M, Pröfrock D, Sanz-Medel A, Prange A (2006) Direct comparison of Capillary Electrophoresis and Capillary Liquid Chromatography hyphenated to collision-cell ICP-MS for the investigation of Cd, Cu and Zn containing metalloproteins. Journal of Chromatograpgy A, 1114, 138-144
  • Kakuschke A, Valentin-Thon E, Fonfara S, Griesel S, Siebert U, Prange A (2006) Metal sensitivity of marine mammals: a case study of a grey seal (Halichoerus grypus). Marine Mammal Science, 22, 985-996
  • Griesel S, Mundry R, Kakuschke A, Fonfara S, Siebert U, Prange A (2006) Mineral elements and essentiel trace elements in blood of seals of the North Sea measured by Total-reflection X-ray fluorescence analysis. Spectrochimica Acta, 61, 1158-1165
  • Li B, Bergmann J, Lassen S, Leonhard P, Prange A (2005) Distribution of elements binding to molecules with different molecular weights in aqueous extract of Antartic krill by size-exclusion chromatography coupled with inductively coupled plasma mass spectrometry. J. Chromatogr. B, 814, 83 - 91
  • Hölemann JA, Schirmacher M, Prange A (2005) Seasonal variability of trace metals in the Lena River and the southeastern Laptev Sea: Impact of the spring freshet. Global and Planetary Change, 48, 112-125
  • Kakuschke A, Valentin-Thon E, Griesel S, Fonfara S, Siebert U, Prange A (2005) Immunological impact of metals in harbour seals (Phoca vitulina) of the North Sea. Environmental Science and Technology, 39, 7568-7575
  • Pröfrock D, Leonhard P, Ruck W, Prange A (2005) Development and characterisation of a new interface for coupling capillary LC with collision-cell ICP-MS and its application for phosphorylation profiling of tryptic protein digests. Analytical and Bioanalytical Chemistry 381, 194-204
  • Knispel T, Ruhnau C, Lassen S, Griesel S, Prange A, Denkhaus E (2005) Nickel species analysis of human colonic tissue using liquid chromatography, gel electrophoresis and mass spectrometry, Analytical and Bioanalytical Chemistry, 383, 404-413
  • Pepelnik R, Karrasch B, Niedergesäß R, Erbslöh B, Mehrens M, Link U, Herzog M, Prange A (2005) Influence on the flooding in 2002 on the plankton and the quality of water and sediment of the river Elbe over its longitudinal profile. Acta Hydrochimica and Hydrobiologica 33, 430-448
  • Prange A, Pröfrock D (2005) Application of CE-ICP-MS and CE-ESI-MS in Metalloproteomics - Challenges, Developments and Limitations. Analytical and Bioanalytical Chemistry, 383, 372-389
  • Bouyssiere B, Knispel T, Ruhnau C, Denkhaus E, Prange A (2004) Analysis of nickel species in cytosols of normal and malignant human colonic tissues using two dimensional liquid chromatography with ICP sector field MS detection. JAAS, 19, 196 -200
  • Aulinger A, Einax JW, Prange A (2004) Setup and optimization of a PLS regression model for predicting element contents in river sediments.Chemometrics and Intelligent Laboratory Systems 72, 35 - 41
  • Bergmann J, Lassen S, Prange A (2004) Determination of the absolute configuration of selenomethionine from antarctic krill by RP-HPLC/ICP-MS using chiral derivatization agents, Anal. Bioanal. Chem. 378, 1624-1629
  • Bouyssiere B, Leonhard P, Proefrock D, Baco F, Wilbur S, Prange A (2004) Determination of sulfur containing compounds in petroleum products by capillary gas chromatography with collision cell ICP-MS, JAAS, 19, 700 - 702
  • Proefrock D, Leonhard P, Wilbur S, Prange A (2004) Determination of heteroelement containing pesticides in environmental samples by GC hyphenated with collision cell ICP-MS as alternative sensitive element specific detector, JAAS, 19, 623 - 631
1998- 2003
  • Proefrock D, Leonhard P, Prange A (2003) Determination of phosphorus in phosphorylated deoxribunucleotides using capillary electrophoresis and high performance liquid chromatography hyphenated to inductively coupled plasma mass spectrometry with an octopole reaction cell. JAAS, 18, 708 - 713
  • Proefrock D, Leonhard P, Prange A (2003) Determination of sulphur in metallothionein like proteins using capillary electrophoresis hyphenated to inductively coupled plasma mass spectrometry with an octopole reaction cell. Anal. Bioanal. Chem. 377, 132 - 139
  • Szpunar J, Lobinski R, Prange A (2003) Hyphenated techniques for elemental speciation in biological systems - Focal Point. Appl. Spectroscopy 57 (2003) 102A - 112A
  • Wolf C, Schaumlöffel D, Richarz A-N, Prange A and Brätter P (2003) CZE-ICP-MS Separation of Metallothioneins in Human Brain: Comparability of Electropherograms Obtained from Different Sample Matrices. Analyst 128, 576 - 580
  • Proefrock D, Prange A, Schaumlöffel D, Ruck W (2003) Species analysis of metallothionein like proteins in liver tissues from Elbe Bream and Roe Deer by capillary electrophoresis - inductively coupled plasma mass spectrometry. Spectrochim. Acta 58B, 1403 - 1415
  • Wang Z and Prange A: Use of Surface-Modified Capillaries in the Separation and Characterization of Metallothionein Isoforms by Capillary Electrophoresis Inductively Coupled Plasma Mass Spectrometry. Anal Chem (2002) 74:626-631
  • Prange A: Speziesanalyse mit gekoppelten Systemen: das Beispiel CE/ICP-MS. Nachrichten aus der Chemie (2002) 50:728-732
  • Prange A and Schaumlöffel D: Hyphenated Techniques for the Characterization and Quantification of Metallothionein Isoforms. - Review-. Anal. Bioanal. Chem. (2002) 373:441-453
  • Aulinger A, Prange A, Schmolke S, Niedergesäss R, Einax J Characterization of the elemental charge of sediments and suspended particulate matter from the river Elbe using multielement analysis combined with chemometrical data evaluation. J. Environ. Monit., (2002) 4: 942 - 949
  • Leonhard P, Pepelnik R, Prange A, Yamada N and Yamada T: Analysis of diluted Seawater at the ng/L-level using an ICP-MS with an Octopole Reaction/Collision Cell. J Anal At Spectrom (2002) 17:189-196
  • Schaumlöffel D, Prange A, Marx G, Heuman KG and Brätter P: Characterization and quantification of metallothionein isoforms by capillary electrophoresis-inductively coupled plasma-isotope-dilution mass spectrometry. Anal Bioanal Chem (2002) 372:155-163
  • Polec K, Schaumlöffel D, Szpunar J, Prange A, Lobinski R Analysis for metal complexes with metallothionein in rat liver by capillary zone electrophoresis using ICP quadrupole MS, ICP double-focussing sector-field isotope dilution MS and electrospray MS detection. J. Anal. At. Spectrom. (2002) 17, 908 - 912
  • Griesel S, Reus U and Prange A: Electro-deposition as a sample preparation technique for total-reflection X-ray fluorescence analysis. Spectrochim. Acta B 56 (2001) 2107-2115
  • Prange A, Schaumlöffel D, Brätter P, Richarz A-N and Wolf Ch: Species analysis of metallothionein isoforms in human brain cytosols by use of capillary electrophoresis hyphenated to inductively coupled plasma-sector field mass spectrometry. Fresenius J Anal Chem (2001) 371:764-774
  • Prange et al. in: ATV-DVWK Deutsche Vereinigung für Wasserwirtschaft, Abwasser und Abfall e.V. Hennef: GfA Gesellschaft zur Förderung der Abwassertechnik e.V. [ed.] Die Elbe und ihre Nebenflüsse : Belastung, Trends, Bewertung, Perspektiven (2000), ISBN 3-933707-63-3 (Download)
  • Frank, B., Reincke, H., Prange, A. Informationssysteme ELISE und ELBIS - Instrumente für Forschung und Praxis: Teil 1 - Das Elbe-Informationssystem ELBIS. In: Gewässerlandschaften (...) ATV-DVWK-Schriftenreihe 21 (2000) ISBN 3-933707-65-X