Stem Cell Modifications - Biomaterials


Selected Publications

  • Dong, J., H. D. Chang, et al. (2013). "Loss of methylation at the IFNG promoter and CNS-1 is associated with the development of functional IFN-gamma memory in human CD4(+) T lymphocytes." Eur J Immunol 43(3): 793-804.
  • Regalo, G. and A. Leutz (2013). "Hacking cell differentiation: transcriptional rerouting in reprogramming, lineage infidelity and metaplasia." EMBO Mol Med 5(8): 1154-1164.
  • Scheller, M., J. Schonheit, et al. (2013). "Cross talk between Wnt/beta-catenin and Irf8 in leukemia progression and drug resistance." J Exp Med 210(11): 2239-2256.
  • Schonheit, J., C. Kuhl, et al. (2013). "PU.1 level-directed chromatin structure remodeling at the Irf8 gene drives dendritic cell commitment." Cell Rep 3(5): 1617-1628.
  • Schonig, K., S. Freundlieb, et al. (2013). "Tet-Transgenic Rodents: a comprehensive, up-to date database." Transgenic Res 22(2): 251-254.
  • Stoilova, B., E. Kowenz-Leutz, et al. (2013). "Lymphoid to myeloid cell trans-differentiation is determined by C/EBPbeta structure and post-translational modifications." PLoS One 8(6): e65169.
  • Courtial, N., J. J. Smink, et al. (2012). "Tal1 regulates osteoclast differentiation through suppression of the master regulator of cell fusion DC-STAMP." FASEB J 26(2): 523-532.
  • Leutz, A. and J. J. Smink (2012). "A TORway to osteolytic disease." Cell Cycle 11(4): 637-638.
  • Smink, J. J. and A. Leutz (2012). "Instruction of mesenchymal cell fate by the transcription factor C/EBPbeta." Gene 497(1): 10-17.
  • Smink, J. J., P. U. Tunn, et al. (2012). "Rapamycin inhibits osteoclast formation in giant cell tumor of bone through the C/EBPbeta - MafB axis." J Mol Med (Berl) 90(1): 25-30.
  • Bollinger, T., A. Leutz, et al. (2011). "Circadian clocks in mouse and human CD4+ T cells." PLoS One 6(12): e29801.
  • Michaelis, M., J. Geiler, et al. (2011). "Glycyrrhizin exerts antioxidative effects in H5N1 influenza A virus-infected cells and inhibits virus replication and pro-inflammatory gene expression." PLoS One 6(5): e19705.
  • Mielke, N., R. Schwarzer, et al. (2011). "Eukaryotic initiation factor 2alpha phosphorylation is required for B-cell maturation and function in mice." Haematologica 96(9): 1261-1268.
  • Schonig, K., D. Kentner, et al. (2011). "Development of a BAC vector for integration-independent and tight regulation of transgenes in rodents via the Tet system." Transgenic Res 20(3): 709-720.
  • Wilke, S., L. Groebe, et al. (2011). "Streamlining homogeneous glycoprotein production for biophysical and structural applications by targeted cell line development." PLoS One 6(12): e27829.
  • Lausen, J., O. Pless, et al. (2010). "Targets of the Tal1 transcription factor in erythrocytes: E2 ubiquitin conjugase regulation by Tal1." J Biol Chem 285(8): 5338-5346.
  • Loew, R., N. Heinz, et al. (2010). "Improved Tet-responsive promoters with minimized background expression." BMC Biotechnol 10: 81.
  • Michaelis, M., J. Geiler, et al. (2010). "Glycyrrhizin inhibits highly pathogenic H5N1 influenza A virus-induced pro-inflammatory cytokine and chemokine expression in human macrophages." Med Microbiol Immunol 199(4): 291-297.
  • Schonig, K., H. Bujard, et al. (2010). "The power of reversibility regulating gene activities via tetracycline-controlled transcription." Methods Enzymol 477: 429-453.
  • Smink, J. J. and A. Leutz (2010). "Rapamycin and the transcription factor C/EBPbeta as a switch in osteoclast differentiation: implications for lytic bone diseases." J Mol Med (Berl) 88(3): 227-233.
  • Wethmar, K., J. J. Smink, et al. (2010). "Upstream open reading frames: molecular switches in (patho)physiology." Bioessays 32(10): 885-893.
  • Wilke, S., J. Krausze, et al. (2010). "Glycoprotein production for structure analysis with stable, glycosylation mutant CHO cell lines established by fluorescence-activated cell sorting." Protein Sci 19(6): 1264-1271.
  • Schwanhausser, B., M. Gossen, et al. (2009). "Global analysis of cellular protein translation by pulsed SILAC." Proteomics 9(1): 205-209.
  • Weidenfeld, I., M. Gossen, et al. (2009). "Inducible expression of coding and inhibitory RNAs from retargetable genomic loci." Nucleic Acids Res 37(7): e50.