Institute of Biomaterial Science


Selected Publications

  • C. Wischke, S. Mathew, T. Roch, M. Frentsch, A. Lendlein, Potential of NOD receptor ligands as immunomodulators in particulate vaccine carriers, J Control Release, 164, 299-306 (2012)
  • Q. Wei, T. Becherer, S. Angioletti-Uberti, J. Dzubiella, C. Wischke, A. T. Neffe, A. Lendlein, M. Ballauff, R. Haag, Protein Interactions with Polymer Coatings and Biomaterials, Angew Chem. Int. Edit. 53 (31), 8004-8031 (2014)
  • C. Wischke, A. T. Neffe, S. Steuer, A. Lendlein, Comparing techniques for drug loading of shape-memory polymer networks–effect on their functionalities, Eur J Pharm Sci, 41, 136–147 (2010)
  • S. Staufenbiel, M. Merino, W. Li, M.-D. Huang, A. Lendlein, R. H. Müller, C. Wischke, Surface characterization and protein interaction of a series of model poly[acrylonitrile-co-(N-vinyl pyrrolidone)] nanocarriers for drug targeting, Int. J. Pharmaceut. 485 (1-2), 87-96 (2015)
  • S. Seiffert, F. Friess, A. Lendlein, C. Wischke, Faster Droplet Production by Delayed Surfactant-Addition in Two-Phase Microfluidic to form thermos-sensitive Microgels, J Colloid Interf Sci 452, 38-42 (2015)
  • C. Wischke, M. Schossig, A. Lendlein, Shape-Memory Effect of Micro-/Nanoparticles from Thermoplastic Multiblock Copolymers, Small 10 (1), 83-87 (2014).
  • C. Wischke, A. T. Neffe, S. Steuer, A. Lendlein, Evaluation of a degradable shape-memory polymer network as matrix for controlled drug release, J Control Release, 138 (3), 243-250 (2009)
  • C. Wischke, J. Weigel, L. Bulavina, A. Lendlein, Sustained release carrier for adenosine triphosphate as signaling molecule, J. Control Release 195, 86-91 (2014)
  • F. Friess, U. Nöchel, A. Lendlein, C. Wischke, Polymer Micronetworks with Shape Memory as Future Platform to Explore Shape-Dependent Biological Effects, Adv. Healthc Mater 3 (12), 1986-1990 (2014)
Publications 2015Publications 2014Publications 2013Publications 2012Publications 2011Publications 2009-2010Publications 2006-200820172016

Publications 2015

  • M. Racheva, O. Romero, K. K. Julich-Gruner, A. S. Ulrich, C. Wischke, A. Lendlein, Purity of mushroom tyrosinase as a biocatalyst for biomaterial synthesis affects the stability of therapeutic peptides, Mater. Res. Soc. Symp. Proc. 1718, 85-90 (2015)
  • C. Wischke, J. Weigel, A. Lendlein, Poly(n-butylcyanoacrylate) Nanoparticles as Carriers for Adenosine triphosphate, Mater. Res. Soc. Symp. Proc. 1718, 131-136 (2015)
  • S. Mathew, C. Wischke, S. Baudis, M. Behl, A.T. Neffe, A. Lendlein, Effect of diisocyanate linkers on the degradation characteristics of copolyester urethanes as potential drug carrier matrices, Eur. J. Pharm. Biopharm 95, 18-26 (2015)
  • F. Stoermann, C. Wischke, A. Lendlein, Photo-Reversibility of Cinnamylidene Acetic Acid Derived Crosslinks in Poly(ε-caprolactone) Networks, Mater. Res. Soc. Symp. Proc. 1718, 49-54 (2015)
  • N. J. Lakhkar, C. Peticone, D. de Silva-Thompson, I. B. Wall, V. Salih, J. C. Knowles, Titanium Phosphate Glass Microspheres as Microcarriers for In Vitro Bone Cell Tissue Engineering, in RSC Smart Materials No. 10, Biointerfaces: Where Material Meets Biology, edited by D. Hutmacher, W. Chrzanowski, 105-132 (2015)

Publications 2014

  • C. Wischke, A. Lendlein, Method for Preparation, Programming, and Characterization of Miniaturized Particulate Shape-Memory Polymer Matrices, Langmuir 30, 2820-2827 (2014)
  • M. Filice, O. Romero, O. Abian, B. de las Rivas, J. M. Palomo, Low ionic liquid concentration in water: a green and simple approach to improve activity and selectivity of lipases, RSC Advances 4, 49115-49122 (2014)
  • S. Mathew, C. Wischke, A. Lendlein, Characterization of protein-adjuvant coencapsulation in microparticles for vaccine delivery, Eur. J. Pharm. Biopharm 87, 403-407 (2014)
  • F. Friess, A. Lendlein, C. Wischke, Photoinduced synthesis of polyester networks from methacrylate functionalized precursors: Analysis of side reactions, Polym Advan Technol 25 (11), 1285-1292 (2014)
  • Q. Wei, T. Becherer, S. Angioletti-Uberti, J. Dzubiella, C. Wischke, A. T. Neffe, A. Lendlein, M. Ballauff, R. Haag, Protein Interactions with Polymer Coatings and Biomaterials, Angew Chem. Int. Edit. 53 (31), 8004-8031 (2014)

Publications 2013

  • C. Wischke, C. Schneider, A. T. Neffe, A. Lendlein, Sustained release hydrogels by in situ polymerized polyalkylcyanoacrylate coating, J Control Release, 172 (1), e22 (2013)
  • B. Trajkovski, A. Petersen, C. Perka, N. Scharnagl, C. Wischke, W. Wagermaier, A. Lendlein, G. N. Duda, Local drug delivery by personalized, intra-operative custom made implant coating, J Biomed Mater Res B - Appl Biomater, 101, 950-963 (2013)
  • C. Wischke, A. T. Neffe, B. D. Hanh, C. F. Kreiner, K. Sternberg, O. Stachs, R. F. Guthoff, A. Lendlein, A multifunctional bilayered microstent as glaucoma drainage devices, J Control Release, 172 (3), 1002-1010 (2013)
  • F. Friess, A. Lendlein, C. Wischke, Morphology of crosslinked poly(ε-caprolactone) microparticles, Mater Res Soc Symp Proc, 1569, mrss13-1569-nn16-02, DOI: 10.1557/opl. 2013.815 (2013)
  • S. Schmidt, T. Roch, S. Mathew, N. Ma, C. Wischke, A. Lendlein, Correlating the Uptake and Dendritic Cell Activation by MDP-loaded Microparticles, Mater Res Soc Symp Proc, 1569, mrss13-1569-nn17-05, DOI: 10.1557/opl. 2013.816 (2013)
  • C. Wischke, C. Schneider, A. T. Neffe, A. Lendlein, Polyalkylcyanoacrylates as in situ formed diffusion barriers in multimaterial drug carriers, J Control Release, 169, 321-328 (2013)
  • C. Wischke, M. Behl. A. Lendlein, Drug releasing shape-memory polymers – the role of morphology, processing effects, and matrix degradation, Expert Opin Drug Del, 10 (9), 1193-1205 (2013)
  • S. Heilmann, S. Küchler, C. Wischke, A. Lendlein, C. Stein, M. Schäfer-Korting, A Thermosensitive Morphine-Containing Hydrogel for the Treatment of Large-Scale Skin Wounds, Int J Pharmaceut, 444 (1-2), 96-102 (2013)
  • C. Wischke, A. Krüger, T. Roch, B. F. Pierce, W. Li, F. Jung, A. Lendlein, Endothelial cell response to (co)polymer nanoparticles depending on the inflammatory environment and comonomer ratio, Europ J Pharm Biopharm, 84 (2), 288-296 (2013)
  • F. Frieß, A. Lendlein, C. Wischke, Investigating side-reactions during UV-induced preparation of oligo(e-capro-lactone) based shape-memory polymer networks, PMSE Preprints, 108, 3 (2013)
  • A. Krüger, J. Görs, A. Zaupa, C. Löwenberg, B. F. Pierce, C. Wischke, A. T. Neffe, F. Jung, A. Lendlein, Influence of physically crosslinked gelatins on the vasculature in the avian chorioallantoic membrane, Clin Hemorheol Microcirc, 55, 133-142 (2013)
  • A. T. Neffe, C. Wischke, M. Racheva, A. Lendlein, Progress in Biopolymer-Based Biomaterials and Their Application in controlled drug delivery, Expert Rev Med Devic, 10 (6), 813- 833 (2013)
  • G. Tripodo, C. Wischke, A. T. Neffe, A. Lendlein, Efficient synthesis of pure monotosylated beta-cyclodextrin and its dimers, Carbohyd Res, 381, 59-63 (2013)

Publications 2012

  • C. Wischke, S. Steuer, A. Lendlein, Determining loading kinetics of drug releasing degradable shape-memory polymers, Mater Res Soc Symp Proc, 1403, 207-212, mrsf11-1403-v14-03 (2012)
  • G. Tripodo, C. Wischke, A. Lendlein, Design of semi-interpenetrating networks based on poly(ethyl-2-cyanoacrylate) and oligo(ethylene glycol) diglycidyl ether, Mater Res Soc Symp Proc, 1403, 21-26, mrsf11-1403-v12-23 (2012)
  • F. Frieß, C. Wischke, M. Behl, A. Lendlein, Oligo(ε-caprolactone)-based polymer networks prepared by photocrosslinking in solution, J Appl Biomater Funct Mater, 10 (3), 273-279 (2012)
  • C. Wischke, K. Kratz, F. Jung, A. Lendlein, Helmholtz Virtual Institute „Multifunctional Materials for Medicine“, BioTOPics, 43, 5-7 (2012)
  • S. Mathew, T. Roch, M. Frentsch, C. Wischke, A. Lendlein, Adjuvant effect of microencapsulated NOD ligands studied in a human phagocytic cell line, J Appl Biomater Funct Mater, 10 (3), 229-236 (2012)
  • W. Li, B. F. Piere, N. Scharnagl, C. Wischke, A. L. Sisson, A. Lendlein, Influence of co-monomer ratio on the chemical properties and cytotoxicity of poly[acrylonitrile-co-(N-vinylpyrrolidone)] nanoparticles, J Appl Biomater Funct Mater, 10 (3), 308-314 (2012)

Publications 2011

  • Y. Kohl, C. Kaiser, W. Bost, F. Stracke, H. Thielecke, C. Wischke, A. Lendlein, K. Kratz, R. Lemor, Near-infrared dye-loaded PLGA nanoparticles prepared by spray drying for photoacoustic applications, Int J Artif Org, 34 (2), 249-252 (2011)
  • S. Mathew, A. Lendlein, C. Wischke, Degradation behavior of porous copolyester microparticles in the light of dynamic changes in their morphology, Macromol Symp, 309/310, 123-133 (2011)
  • C. Wischke, J. Weigel, A. T. Neffe, A. Lendlein, Understanding instability and rupture of poly(alkyl-2-cyanoacrylate) capsules, Int J Artif Org, 34 (2), 243-248 (2011)
  • M. Loebler, K. Sternberg, O. Stachs, R. Allemann, N. Grabow, A. Roock, C. Kreiner, D. Streufert, A. T. Neffe, B. D. Hanh, A. Lendlein, K.-P. Schmitz, R. Guthoff, Polymers and drugs suitable for the development of a drug delivery drainage system in glaucoma surgery, J Biomed Mater Res B, 97 (2), 388-395 (2011)
  • A. Lendlein, C. Wischke, How to accelerate biomaterial development? Strategies to support the application of novel polymer-based biomaterials in implantable devices, Expert Rev Med Device, 8 (5), 533-537 (2011)
  • C. Wischke, A. Lendlein, Systeme zur kontrollierten Wirkstofffreisetzung, Technologiereport „Regenerative Medizin in Berlin und Brandenburg“, HRSG: BioTOP Berlin-Brandenburg, 80-82 (2011)
  • G. Tripodo, C. Wischke, A. Lendlein, Highly flexible poly(ethyl-2-cyanoacrylate) based materials obtained by incorporation of oligo(ethylene glycol) diglycidyl ether, Macromol Symp, 309/310, 49-58 (2011)
  • C. Wischke, M. Löbler, A. T. Neffe, B. D. Hanh, M. Zierke, K. Sternberg, K-P. Schmitz, R. Guthoff, A. Lendlein, A Blend of Poly(ε-caprolactone) and Poly[(ε-caprolactone)-co-glycolide] with Remarkable Mechanical Features and Wide Applicability as Biomaterial, Macromol Symp, 309/310, 59-67 (2011)
  • C. Wischke, A. Lendlein, Designing multifunctional polymers for cardiovascular implants, Clin Hemorheol Microcirc, 49, 347-355 (2011)
  • C. Wischke, G. Tripodo, N.-Y. Choi, A. Lendlein, Hydrolytic Degradation Behavior of Poly(rac-lactide)-block-poly(propylene glycol)-block-poly(rac-lactide) Dimethacrylate Derived Networks Designed for Biomedical Applications, Macromol Biosci, 12, 1637-1646 (2011)
  • Y. Kohl, C. Kaiser, W. Bost, F. Stracke, M. Fournelle, C. Wischke, H. Thielecke, A. Lendlein, K. Kratz, R. Lemor, Preparation and Biological Evaluation of Multifunctional PLGA-Nanoparticles designed for Photoacoustic Imaging, Nanomed – Nanotechnol, 7 (2), 228-237 (2011)
  • V. Krasteva, V. Pehlivanova, B. Seifert, K. Lützow, I. Tsoneva, K. Richau, A. Lendlein, R. Tzoneva, Influence of AC electric fields on the adsorption of plasma proteins onto nano-fiber biomaterials, Proceedings of the Bulgarian Academy of Sciences, Cr Acad Bulg Sci, 64 (4), 535-544 (2011)

Publications 2009-2010

  • C. Wischke, A. T. Neffe, S. Steuer, A. Lendlein, Amorphous polymer networks combining three functionalities: shape-memory, biodegradability, and drug release, in Active Polymers, edited by A. Lendlein, V. Prasad Shastri, Ken Gall, Mater Res Soc Symp Proc, 1190, 131-136, 1190-NN11-34 (2009)
  • C. Wischke, A. Lendlein, Shape-Memory Polymers as Drug Carriers—A Multifunctional System, Pharm Res, 27 (4), 527 (2010)
  • C. Wischke, Y. Zhang, S. Mittal, S. P. Schwendeman, Development of PLGA-based injectable delivery systems for hydrophobic fenretinide, Pharm Res, 27 (10), 2063-2074 (2010)
  • F. Jung, C. Wischke, A. Lendlein, Degradable, Multifunctional Cardiovascular Implants: Challenges and Hurdles, MRS Bull, 35 (8), 607-613 (2010)
  • C. Wischke, A. T. Neffe, A. Lendlein, Controlled Drug Release from Biodegradable Shape-Memory Polymers, Adv Polym Sci, 226, 177-205 (2010)
  • A. T. Neffe, B. D. Hanh, S. Steuer, C. Wischke, A. Lendlein, Thermomechanical Properties and Shape-Memory Capability of Drug Loaded Semi-Crystalline Polyestermethacrylate Networks, in Active Polymers, edited by A. Lendlein, V. Prasad Shastri, K. Gall, Mater Res Soc Symp Proc, 1190, 105-111, 1190-NN06-02 (2009)
  • C. Wischke, J. Zimmermann, B. Wessinger, A. Schendler, H. H. Borchert, J. H. Peters, T. Nesselhut, D. R. Lorenzen, Poly(I:C) coated PLGA microparticles induce dendritic cell maturation, Int J Pharm 365 (1-2), 61-68 (2009)
  • C. Wischke, A. T. Neffe, S. Steuer, E. Engelhardt, A. Lendlein, AB-polymer networks with cooligoester- and poly(n-butyl acrylate)-segments as multifunctional matrix for controlled drug release, Macomol Biosci, 10 (9), 1063-1072 (2010)
  • A. Lendlein, M. Behl, B. Hiebl, C. Wischke: Shape-memory polymers as a technology platform for biomedical applications, Expert Rev Med Devices, 7 (3), 357-379 (2010)

Publications 2006-2008

  • H. D. Volk, G. Duda, A. Lendlein, Berlin-Brandenburg Center for Regenerative Therapies, TERMIS, Newsletter, 1 (3), 15-20 (2006)
  • J. Borstlap, A. Lendlein, G. Duda, S. Mundlos, M. Sittinger, U. Dirnagl, J. Gerlach, P. Reinke, H.-D. Volk, Translating Novel Scientific Findings into Regenerative Therapies, Tissue Eng Pt A, 14 (5), 792 (2008)
  • C. Wischke, S. P. Schwendeman, Principles of encapsulating hydrophobic drugs in PLA/PLGA microparticles, Int J Pharm, 364 (2), 61-68 (2008)
  • H. G. Hicke, M. Becker, B. R. Paulke, M. Ulbricht, Covalently coupled nanoparticles in capillary pores as enzyme carrier and as turbulence promoter to facilitate enzymatic polymerizations in flow-through enzyme-memnbrane reactors, J Memb Sci, 282, 413-422 (2006)
  • W. Li, C. Nesselmann, Z. Zhou, L. L. Ong, F. Öri, G. Tang, A. Kaminski, K. Lützow, A. Lendlein, A. Liebold, et al., Gene delivery to the heart by magnetic nanobeads, J Magn Magn Mater, 311 (1), 336-341 (2007)


  • N. Brunacci, C. Wischke, T. Naolou, A. T. Neffe, A. Lendlein, lnfluence of surfactants on depsipeptide submicron particle formation, Eur. J. Pharm. Biopharm 116, 61-65 (2017)
  • N. Zhang, A. Said, C. Wischke, V. Kral, R. Brodwolf, P. Volz, A. Boreham, C. Gerecke, W. Li, A. T. Neffe, B. Kleuser, U. Alexiev, A. Lendlein, M. Schäfer-Korting, Poly[acrylonitrile-co-(N-vinyl pyrrolidone)] nanoparticles - composition-dependent skin penetration enhancement of a dye probe and toxicity, Eur. J. Pharm. Biopharm 116, 66-75 (2017)
  • D. Ceylan Tuncaboylu, C. Wischke, F. Störmann, A. Lendlein, Microgels from microfluidic templating and photoinduced crosslinking of cinnamylidene acetic acid modified precursors, React. Funct Polym 112, 68-73 (2017)
  • C. Löwenberg, M. Balk, C. Wischke, M. Behl and A. Lendlein, Shape-Memory Hydrogels: Evolution of Structural Principles To Enable Shape Switching of Hydrophilic Polymer Networks, Acc Chem Res 50 (4), 723-732 (2017)


  • F. Friess, A. Lendlein, C. Wischke, Two phase microfluidics with inviscid drops: Effects of total flow rate and delayed surfactant addition, MRS Advances 1 (27), 2019-2027 (2016)
  • M. Balk, M. Behl, C. Wischke, J. Zotzmann, A. Lendlein, Recent Advances in Degradable Lactide-Based Shape Memory Polymers, Adv Drug Deliver Rev 107, 136-152 (2016)
  • C. Wischke, A. Lendlein, Functional nanocarriers by miniaturization of polymeric materials, Nanomedicine 11 (12), 1507-1509 (2016)
  • Y. Zhang, C. Wischke, S. Mittal, A. Mitra, S. Schwendeman, Design of controlled release PLGA microspheres for hydrophobic fenretinide, Mol Pharmaceut 13 (8), 2622-2630 (2016)
  • C. Wischke, E. Rühl, A. Lendlein, Dermal Drug Delivery by Nanocarriers, J. Contr. Release 242, 1-2 (2016)
  • A. Vogt, C. Wischke, A. T. Neffe, N. Ma, U. Alexiev, A. Lendlein, Nanocarriers for drug delivery into and through the Skin - Do existing technologies match clinical challenges? J. Contr.Release 242, 3-15 (2016)
  • M. Balk, M. Behl, J. Yang, Q. Li, C. Wischke, Y. Feng, A. Lendlein, Design of Polycationic Micelles by Self-Assembly of Polyethyleneimine Functionalized Oligo[(ε-caprolactone)-co-glycolide] ABA Block Copolymers, Polym Adv Technol 2017 [E-pub ahead of print on Sept. 29, 2016], doi: 10.1002/pat.3911
  • T. Bhuvanesh, S. Saretia, T. Roch, A.-C. Schöne, F. O. Rottke, K. Kratz, W. Wang, N. Ma, B. Schulz, A. Lendlein, Langmuir-Schaefer films of fibronectin as designed biointerfaces for culturing stem cells, Polym Adv Technol 2017, [E-pub ahead of print on Sept. 30, 2016], doi: 10.1002/pat.3910
  • A. D. Bianco, C. Wischke, S. Zhou, A. Lendlein, Controlling surface properties and permeability of polyglycerol network films, Polym Adv Technol 2017, [E-pub ahead of print on Oct. 12, 2016], doi: 10.1002/pat.3917