Nanoparticles (red) taken up by macrophages within 24 hours (RAW-Blue Cells, cell nucleus blue, cell skeleton green)
The research group Pharmaceutical Technology develops controlled delivery systems for bioactive molecules to be used in parenteral administration. These systems are based on polymers ranging e.g. from hydrophobic (co)polyesters to very hydrophilic materials. From such polymers, a variety of drug carriers can be prepared.
In addition to research based on new materials and new carrier concepts for controlled delivery, the research group also addresses further key elements of translational biomaterial research such as sterilization of carrier systems and aseptic preparation in a GMP conform clean room.
Variety of Carrier Systems
The selection of a suitable carrier systems requires consideration of demands set by the specific application and the properties of the bioactive substances. The studied carrier systems range from injectable micro/ nanoparticles to preformed implants like rods or polymeric stents, in situ forming implants, or hydrogels.
Examples of carrier systems for controlled drug delivery
New Polymer Systems and Technologies for Pharmaceutical Sciences
The work of the research group Pharmaceutical Technology includes new concepts for drug carriers which are driven by the material development in this group and other departments of the Institute of Biomaterial Science. Tailorable properties and functions of new polymers are a cornerstone for establishing novel systems for controlled delivery.
In several cases, carriers systems may be formed in integrated processes such as simultaneous drug loading and crosslinking of polymer networks. While integrated processes may add complexity into the respective preparation step, they may substantially shorten the preparation time and/or be needed to establish distinct functions of carrier systems.
Microfluidic formation of a double emulsion
The movie shows the microfluidic formation of a double emulsion (droplet-in-droplet) for encapsulation of substances whose downstream processes can be combined, e.g. with the induction of a crosslinking reaction.