Logo EU 7. Rahmenprogramm

Conducting projects at the European level has a year-long tradition at the Helmholtz-Zentrum Geesthacht.

In the EU-funded project TEH-TUBE of the 7th Framework Programme the Helmholtz-Zentrum Geesthacht acts as a project participant.

Tissue engineering of the right heart outflow tract by a biofunctionalized bioresorbable polymeric valved tube

Approximately 42% of infants’ mortality in the world is related to congenital heart defects. Over 1/3 require the reconstruction of the right ventricular outflow tract by surgical procedures which currently use inert materials without any growth potential. Consequently, multiple reoperations are often required, with their attendant high risk of mortality and morbidity.

The TEH-TUBE project will address these limitations by creating a novel bioabsorbable biomaterial using a polymeric valved tube either seeded with autologous adipose tissue derived stem cells (ADSC) or functionalized by a peptidic sequence triggering homing of the host cells onto the scaffold to make it a living self-populated structure.

Key objectives of the project are:

  • 1.) Compare three different polymers processed by electrospinning to generate a competent valved tube
  • 2.) Compare, in the selected polymer, ADSC seeding and peptide grafting using in vitro mechanical and biological tests as well as in vivo animal experiments
  • 3.) Validate the ultimate combination (polymer + cells or peptides) in a clinically relevant large animal mode (in this case, the growing lamb to specifically assess the regenerative and growth potential of the composite construct).

This stepwise approach will be conducted within a tightly controlled regulatory framework to ensure that the final product meets the current ATMP (Advanced Therapy Medicinal Product) requirements for phase I/II clinical studies and, if successful, ultimate commercialization.

The TEH-TUBE project aims at developing an innovative biomaterial for the treatment of congenital heart abnormalities in children and young adults. HZG will lead the work package on polymer biofunctionalization.


  • Assistance Publique - Hopitaux De Paris (FR)
  • EURAM Limited (GB),
  • University College London (GB)
Project Details
Start Date
January 2014
End Date
December 2017
48 months
EU-Programme Acronym and Subprogramme Area
Project Type
Collaborative Project
Contract Number
Grant Agreement 604049
Assistance Publique - Hopitaux de Paris, FR