Lipid droplet formation indicates adipogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs) on poly(styrene-co-acrylonitrile) surface with micro-scale roughness.
Regenerative Medicine holds great promise to alleviate morbidity and mortality in patients suffering from organ failure. Accumulating clinical and experimental evidence indicate that stem cells are promising cell types to reconstruct the damaged tissues in the treatment of various degenerative disorders due to the self-renewing and differentiation potential.
Stem cells are very sensitive to their local extracellular environment. A range of stem cell responses, such as cell adhesion, viability and differentiation, can be differentially affected by particular local environment. Local extracellular environment could modulate different signaling pathways that govern stem cell behavior and organ development, and influence endogenous tissue repair and regeneration.
Another focus of the Department Polymers in Regeneration is the interaction of immune cells with biomaterials. Almost every implant causes inflammatory reactions, which can lead to swelling and pain at the side of implantation and could in the worst case result in implant rejection requiring its replacement.
One goal is to determine the immunological characteristics physicochemical and mechanical properties of biomaterials facilitate the development of immunologically inert or even immune suppressive biomaterial. To optimally support regenerative processes, immune-compatible biomaterials capable of controlling stem cell behavior are investigated and developed in the department.