Osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs) on poly(styrene-co-acrylonitrile) surface with micro-scale roughness (Bone cell-specific markers in red: alizarin red S)
The department of biocompatibility places value on the investigation of cell and biomaterial interactions. The aim is to analyse the various material features for cell material interactions and to determine their influence on (stem) cell function, self-renewal and tissue regeneration. The natures of biomaterials, such as the elasticity, roughness, geometry, anisotrophy and surface chemistry could strongly influence the functions and fate of stem cells.
Aiming to provide knowledge based information on the design and development of novel biomaterials using the state of the art technologies, our research is directed to investigate the process and mechanism of crosstalk between stem cells and various biomaterials with different physical and chemical properties.
Furthermore, the influence of biomaterials on the cellular behavior of these stem cells is studied. Based on rational design principles, our understanding on how biological, chemical and physical cues as well as their spatiotemporal coordination regulate cell response could consequently improve the engineering of functional biomaterials.