PhD position (m/f)
|Beginn der Ausschreibung||20.07.2018|
|Ende der Ausschreibung||16.08.2018|
|Institut||Institut für Werkstoffforschung|
The Helmholtz Zentrum Geesthacht (HZG) is one of the leading developers of magnesium - based implants for various applications, e.g. orthopedics and cardiovascular, with the goal to promote the healing of the tissue. The research centre hosts the studies of the development of magnesium - based implants which consists of improving the mechanical and degradation performance of the metal, characterisation, processing and in vitro biological testing of the newly developed implant materials. This research is extended to in vivo performance studies at the outstation of HZG, Molecular Imaging North Competent Centre (MOIN CC) in Kiel (http://www.moincc.de).
We are seeking to fill a position on the topic ‘’Evaluation of structural and mechanical changes in bone in response to magnesium - based implants in diabetes rat model using multimodal imaging’’ at our outstation, MOINCC in Kiel. We therefore invite applications for a PhD (m/f) position. The position is initially limited to 3 years, starting date as soon as possible. The place of employment is Kiel, Helmholtz-Zentrum Geesthacht outstation at Molecular Imaging North Competence Center (MOIN CC).
The focus of the project is the study of the bone healing process in a diabetes rat model using advanced and sophisticated imaging modalities at the HZG outstation at MOIN CC in Kiel and to a certain extent also at the synchrotron beamlines operated by HZG at DESY in Hamburg. Your work will also include evaluation of immune responses to Mg alloys and to visualise the process of vascularisation using specific markers.
You will be responsible for:
- measuring the bone formation and mineralisation around a degradable Mg-based implant using tomography, histomorphometery and push out tests established at the HZG synchrotron beamline in Hamburg
- evaluating the bone healing process such as formation of type III collagen using molecular imaging and assessing the pro-inflammatory and anti-inflammatory cytokine levels to identify the inflammatory environment in presence of Mg implants
- identifying the markers of vascularization and visualizing them at the site of implantation by multi-photon microscopy or optical imaging
- the biological characterisation of tissue-to-implant interface by histology, immunohistochemistry and molecular imaging
This position requires a Master’s degree in natural sciences - physics, mathematics, biology, (bio-)medical engineering, theoretical medicine or other related disciplines. We ask for a theoretical background on medical imaging and bone formation process with strong analytical skills and proven experience in at least one of the following techniques: optical imaging, multi-photon microscopy, tomography and MRI. Initial experience in in vivo imaging experiments is desirable. You should exhibit team spirit, excellent communication and organization skills as well as a sound expertise of English language.
- multinational work environment with over 900 colleagues from more than 50 nations
- extensive options of vocational training (i. a. expert seminars, language courses or leadership seminars)
- flexible working hours and various models to ensure the compatibility of family and career
- excellent infrastructure including modern work spaces
- remuneration according to the standards of the collective wage agreement TV-AVH including further social benefits
The Helmholtz-Zentrum Geesthacht is an equal opportunity employer and particularly strives to increase the percentage of women in the science sector. Severely disabled persons with equal qualifications will be considered preferentially within the framework of legal requirements.
Please send your application indicating job offer
code-no. 2018/WB 3
including your CV, description of your scientific studies and projects, copies of credentials including grades, documentation of your English skills (TOEFL, IELTS or equivalent) and two letters of recommendation, preferably by e-mail in one file not larger than 10 MB to
Closing date for applications is August 16, 2018.